Genetic Data Processing and Variant Analysis REST API

Develop a comprehensive REST API using Django REST Framework for processing and analyzing genetic sequencing data. Create endpoints that can handle large genomic datasets, implement advanced filtering for genetic variants, and provide machine learning-powered predictive analysis for genetic risk assessments. Include sophisticated authentication with multi-factor verification, support for multiple genetic file formats (VCF, BAM, FASTQ), and implement secure data compartmentalization. Design the API to handle computational-intensive tasks using Celery for background processing and provide detailed audit logging for compliance requirements.