Genomic Variant Analysis with Streaming JavaScript

Create a Node.js microservice for processing and analyzing large-scale genomic variant data, capable of handling VCF (Variant Call Format) files up to 50GB. Implement a streaming parser that can identify rare genetic mutations, calculate population frequency, and generate statistical reports. Use RxJS for reactive data processing, develop a machine learning classification system for variant pathogenicity, and create a secure API for distributing anonymized genetic analysis results. Include comprehensive error handling for incomplete or corrupted genomic datasets.