Advanced Medication Interaction Risk Detection System

Develop a complex SQL-based pharmaceutical interaction detection framework. Create a multi-dimensional query system that: 1) Analyzes patient medication histories, 2) Cross-references comprehensive drug interaction databases, 3) Generates real-time risk scores for potential adverse interactions, 4) Implements adaptive machine learning models to improve detection accuracy over time. Include robust error handling, performance optimization for large medication databases, and compliance with FDA interaction classification standards.