Genomic Data Stream Processing with Reactive TypeScript

Design a type-safe, reactive pipeline for processing large-scale genomic sequencing data using RxJS and TypeScript. Create a system that can handle real-time streaming of genetic mutation data, implement backpressure mechanisms, and provide type-safe transformations for different genomic file formats (VCF, FASTQ). Include error handling for corrupted data streams and implement a generic typing system that allows for extensible genetic data processing.