Clinical Trial Randomization and Allocation System

Build a comprehensive Python application for managing clinical trial participant randomization using stratified block randomization techniques. The system must securely handle participant enrollment, generate randomization schedules with configurable block sizes, ensure allocation concealment, and maintain detailed audit logs. Implement cryptographically secure random number generation and support multiple randomization algorithms including simple, permuted block, and adaptive designs. Include robust data validation and export capabilities compatible with FDA regulatory requirements.