Cross-Institutional Clinical Trial Data Harmonization Platform

Create a comprehensive database architecture for harmonizing clinical trial data across multiple research institutions with disparate data collection methods. Develop a schema that: 1) Supports dynamic schema evolution, 2) Implements robust data validation frameworks, 3) Enables secure multi-party data collaboration, and 4) Provides transparent data provenance tracking. Include strategies for handling conflicting data standards and demonstrating statistical equivalence across different research protocols.